The time-dependent prognostic value of coronary computed tomography angiography in symptomatic patients

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): State Research for Turku University Hospital. Background Coronary computed tomography angiography (CCTA) is recommended diagnostic workup coronary artery disease (CAD) and known to provide prognostic information. However, it unknown whether there time-dependent variation in the strength CCTA. Purpose To study time-varying value CCTA patients with suspected CAD. Methods From two academic medical centers, we identified symptomatic who underwent A composite endpoint all-cause mortality myocardial infarction was recorded. The non-obstructive or obstructive (≥50%) CAD assessed by Cox proportional hazard model. power model according cumulative length follow-up evaluated measuring area under receiver operating characteristic (ROC) curve (AUC) as a function time (time-dependent AUC). Results total 2662 (age 61 ± 10 years, 45% male) were included, 247 adverse events (9%) during median 6.9 years (25th–75th percentile 4.9–8.8 years; maximum 13.3 years). Based on CCTA, 804 (30%) had no CAD, 963 (36%) 895 (34%) presence (adjusted HR 2.24; p = 0.002) 4.42; p<0.001) independent predictors outcome. predictive findings relatively stable until time, demonstrated Figure showing AUC adjusted (solid line) 95% confidence intervals (dashed lines). including only clinical variables shown comparison. Conclusion CTA retain their at least 10-year